Jul 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 45 references
Medicine
TL;DR
MAL exhibits potent anti-inflammatory and analgesic properties, particularly at 25 mg/kg, reducing neutrophil-mediated inflammation, and represents a promising candidate for further pharmacological development.
The studied compounds of the indenopyrrole series and their indenopyridazine derivatives are virtually non-toxic compounds, exhibit an anti-inflammatory effect and reduce the severity of pain associated with inflammation.
O. N. Gein, N. V. Nosova, E. Chizhova et al.· Acta Biomedica Scientia· 0 citations
The findings suggest that OA possesses pronounced antinociceptive and anti-inflammatory properties, however, the reduced efficacy observed with combined administration and the elevation of cytokines indicate that OA and LA might work via different pathways, thus warranting further investigation into their dose-dependen...
A. Öner, Esin Akarsu Orunç· The Veterinary Journal· 0 citations
Azilsartan exhibits significant anti-inflammatory and inflammation-associated pain–modulating effects in preclinical models, but does not demonstrate significant analgesic activity in acute thermal nociception.
S. Atal, Santenna Chenchula, P. Ponmani et al.· Beni-Suef University Journal...· 0 citations
It was evaluated in this study that aripiprazole showed inhibition of protein degradation and stability of human red blood cell membrane in concentration gradient manner, demonstrating maximum activity at concentration of 6400 µg/ml.
Aroosa Akber, Alamgeer, H. Irfan et al.· InflammoPharmacology· 0 citations
It is demonstrated that TriQ exerts potent anti-inflammatory and antioxidant effects primarily through modulation of the NF-κB/HO-1 signaling axis, highlighting its potential as a promising lead candidate for the development of novel anti-ulcerative colitis therapeutics.
A. Qadir, S. Khan, Humaira Nadeem et al.· Biochemical and Biophysical...· 0 citations
Compounds 4a and 4f show selective COX-2 inhibition as potent antiinflammatory agents for the treatment of inflammatory diseases and the pharmacokinetic properties suggest that 4f can be categorized as a drug-like compound.
Si-Yuan Ma, Jiayi Cai, Zixuan Yang et al.· Medicinal chemistry· 0 citations
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