TL;DR
Conurrent downregulation of IGFL2-AS1 and BRCA1 at transcript and protein levels was observed in EC tissues, with a positive correlation between their expression levels.
Background: Breast cancer is one of the most common malignancies in women. A major challenge in its diagnosis and treatment is the lack of adequate molecular targets. Various risk factors can influence the likelihood of developing breast cancer. Reduced expression of long noncoding RNAs (lncRNAs), such as OIP5-AS1 and...
A positive correlation among the expression of hsa-miR-184, hsa-miR-190b, and SCGB2A2 suggests that they may participate in shared biological pathways that govern critical cellular processes, such as membrane trafficking and cell signaling, which are frequently disrupted in cancer.
This study found that LINC02257 and LINC00659 are upregulated in BC and are associated with malignancy-related genes and patient survival, suggesting their potential as therapeutic targets and prognostic biomarkers.
ULBP1 may serve as a potential novel prognostic biomarker in BC, and targeting ULBP1 may provide a new therapeutic strategy for BC.
Functional validation utilizing CCK-8 and transwell assays revealed that IGFBP1 silencing significantly suppressed the proliferative, invasive, and migratory capabilities of ESCA cell lines, and in vivo analyses presented similar results.
Higher expression of all six lncRNAs in gastric cancer was associated with unfavourable overall survival and co-expression enrichment identified several cancer-associated pathways, most prominently epithelial–mesenchymal transition.
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