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Structural MRI signature predicts tau staging in Alzheimer's disease

Martina Pulze S. Garbarino L. Lorenzini A. Cirone Shahzad Ali L. Gualco F. Massa Dario Arnaldi B. Orso M. Losa W. Kreshpa S. Caneva Matteo Parodi Luca Sofia S. Raffa G. Sambuceti Massimo Caulo E. Pravatà Fabrizio Levrero Marco Bozzali S. Morbelli M. Piana A. Uccelli L. Roccatagliata Andrea Chincarini M. Pardini

Jul 2026 · Alzheimer's & Dementia · Vol 18 · 0 citations · 22 references

Medicine

TL;DR

Evidence is provided that multiregion T1‐MRI patterns can inform on tau‐PET burden in AD and may support approximate tau staging when tau‐PET is unavailable, especially in subjects with more advanced tau burden.

Abstract

Tau positron emission tomography (PET) probes Alzheimer's disease (AD) severity via regional tau spread but is not widely available. We tested whether multiregion structural magnetic resonance imaging (MRI) could approximate individual tau burden.

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