Association of Lifestyle Behaviors and Cancer Risk in MetALD

Abstract

Simple Summary People with metabolic and alcohol-associated liver disease may have a higher risk of developing cancer, but it remains unclear how combinations of smoking, physical activity, and diet affect this risk. We studied 25,712 participants from the UKi Biobank to examine whether healthier or less healthy lifestyle patterns were related to new cancer diagnoses. During follow-up, 4416 participants developed cancer. Having more favorable behaviors tended to be associated with a lower cancer risk, whereas having more adverse behaviors tended to be associated with a higher risk, although the pattern was not consistent across every category. Current smoking showed the clearest association with increased cancer risk. Therefore, lifestyle assessment including smoking status may help identify people with metabolic and alcohol-associated liver disease who are at greater cancer risk.