Open access
Design of bifunctional pyridinophane ligands as Mn 2+ MRI agents for diagnostic imaging of Alzheimer's disease
T. El Sayed
Akhil Patel
Jennifer A. Salaiza
Husna Azhakath Valappil
Liviu M. Mirica
Ke-Rui Xu
Shreyan Majumdar
Brad Sutton
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose prevalence is rising with the aging of the global population. Among the proposed pathological hallmarks, the amyloid-beta (Aβ) peptide aggregates and...