Open access
Scutellarin Alleviates Neuronal Apoptosis After Ischemia and Hypoxia via the HIF‐1α–CX3CR1 Axis
Jing-Chun Pei
Bin Hu
Zhong-Hui Wen
Cheng Wan
Fu-Qing Zhang
Shao-Xiang Li
Lei Wang
Zhi-Gao Li
Zhi-Wei Tang
Medicine
Abstract
Stroke is a significant health threat characterized by high incidence, mortality, disability, recurrence, and complications. Over 70% of strokes are ischemic in nature. Reducing neuronal apoptosis following ischemic–hypoxic injury is crucial for effective treatment. This study investigates the direct neuroprotective effects of scutellarin after ischemia–hypoxia, clarifies the relationship between upregulated CX3CR1 expression and neuronal apoptosis, and elucidates the mechanism by which scutellarin regulates apoptosis through the HIF‐1α–CX3CR1 axis. This research provides a robust theoretical foundation for the clinical application of scutellarin in the management of ischemic stroke.