Prognostic value of D-SPECT-derived myocardial flow reserve in detecting coronary microvascular disease and predicting outcomes after complete revascularization: a two-center pilot study.
Sep 2026· European Journal of Nuclear Medicine and Molecular Imaging· 0 citations· 28 references
Medicine
TL;DR
In this two-center cohort of patients with complete revascularization after PCI, D-SPECT-derived CMD is associated with a 2-fold increased risk of future MACE, independent of traditional risk factors and perfusion abnormalities.
BACKGROUND
Left main (LM) and multivessel coronary disease (MVD) are high-risk conditions in which surgical revascularization may be preferred over medical or percutaneous therapies, yet may be missed by conventional imaging. Vasodilator stress perfusion cardiac magnetic resonance (CMR) appeared promising in resolving...
Benedikt Bernhard, M. Daibes, Isabela Reis Marques et al.· JACC Cardiovascular Imaging· 1 citation
Highlights
The study demonstrates that in patients with uncomplicated STEMI and intermediate stenoses of non-infarct-related arteries, performing staged complete revascularization only with a hemodynamically significant fractional flow reserve (FFR) value ≤ 0.80 at 30–45 days after primary intervention is associat...
K. Ibragimova, T. Sukhinina, G. Arutyunyan et al.· Complex Issues of Cardiovasc...· 0 citations
BACKGROUND
Coronary artery disease frequently coexists with severe aortic stenosis (AS) and contributes to adverse outcomes after transcatheter aortic valve implantation (TAVI). Conventional lesion-based assessments may underestimate the cumulative impact of diffuse coronary physiologic impairment in this population. T...
Enrico Paolo Legaspi, P. Serruys, Tsung-Ying Tsai et al.· Catheterization and cardiova...· 0 citations
BACKGROUND
The diagnostic value of coronary computed tomography angiography-derived fractional flow reserve (FFR-CT) in stable coronary artery disease is well established. The prognostic value of predicting future cardiovascular events is less clear, as studies are limited by small populations, variable measurement poi...
Jack S. Bell, Edward D. Nicol, Vinod Venugopal et al.· Circulation· 0 citations
Coronary artery disease (CAD) is a major cardiovascular health problem. Myocardial perfusion imaging (MPI), especially single-photon emission computed tomography (SPECT), provides valuable diagnostic and prognostic information after percutaneous coronary intervention (PCI). The Synergy Between PCI with TAXUS and Cardia...
Muneer Saif Abdulkhaleq Mohammed Alshameery, Islam Shawky Abd El-Aziz Saif El-Yazal, Mohamad Ahmad Mosaad Zaki· Cardiology and Angiology An...· 0 citations
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