Protective and Antioxidant Effects of Moringa oleifera Extract Against Cisplatin-Induced Renal Injury in Male Rabbits

Abstract

Cisplatin, which can be very effective as a chemotherapeutic agent, is considerably limited in its clinical application by its known tendencies towards nephrotoxicity, a problem that is mainly due to oxidative stress, inflammation and tubular damage. To appraise the ameliorative and antioxidant action of Moringa oleifera extract on cisplatin-induced renal trauma in male rabbits. Thirty-two adult male rabbits were randomly allocated to four groups control group ; the cisplatin treatment group; the cisplatin plus Moringa group; and a fourth group which only received Moringa extracts without any cisplatin exposure. Kidney injury was induced by cisplatin (5 mg/kg). Moringa oleifera extract in such an amount as 300 mg × kg(-1) was given orally every day for 30 days. After this period of time we saw Cisplatin administration led to severe renal dysfunction by marked increases in serum urea, creatinine and Kidney Injury Molecule-1 (KIM-1)  along with prominent oxidative stress as evidenced by GSH and SOD decrease, NO and MDA increase. Co-treatment with Moringa oleifera could greatly improve kidney function indexes and reduced KIM-1 concentration, suggesting the attenuation of tubular injury. In addition, while significantly decreasing levels of NO and MDA, it helped the antioxidant system: Moringa restored deficiency in GSH and SOD. In conclusion, these findings suggest that Moringa oleifera has a protective effect against cisplatin-induced renal injury. This extract clearly exerts antioxidant effects and has anti-inflammatory properties, thereby effectively eliminating oxidative damage caused during the use of cisplatin. It can ensure good kidney function .