Sep 2026· Cancer Chemotherapy and Pharmacology· Vol 96· 0 citations· 48 references
Medicine
TL;DR
The findings suggest that TNF-α responsiveness, cIAP1 (BIRC2)-related signaling, and the ability of cancer cells to activate apoptotic pathways, particularly caspase-8, may serve as potential biomarkers for identifying tumors more likely to respond to Birinapant-based combination therapies.
It is suggested that gramine inhibits malignant progression and attenuates cisplatin resistance in OC cells, at least in part, through blockade of the PDK1/AKT pathway.
Hai-Yan Wang, Ruiming Zheng, Bujun Wang et al.· Experimental and Therapeutic...· 0 citations
Findings indicate that tomentosin exerts antiproliferative and pro-apoptotic effects in A549 cells and that combined exposure with cisplatin is associated with a greater biological response under the investigated in vitro conditions.
Hilal Nakkaş, Beyza Ecem Oz-Bedir, Emine Terzi et al.· Current Issues in Molecular...· 0 citations
Background/Aim: Sorafenib is a standard targeted therapy for renal cell carcinoma; however, resistance and limited efficacy remain clinical challenges. Magnolol, a bioactive compound derived from Magnolia officinalis, exhibits anti-cancer properties, and may enhance therapeutic responses. This study investigated whethe...
Che-Cheng Chang, Man-Yun Hung, Yueh-Shan Weng et al.· In Vivo· 0 citations
These findings identify the FOXD1/β-catenin/DARS2 axis as a potential therapeutic target for overcoming cisplatin resistance in BLCA clinically and promote cisplatin resistance in BLCA.
Xian-Yong Li, Ming-Qiang Su, Jing-Xian Luo et al.· Urologic oncology· 0 citations
It was revealed that BLA could reduce MCF-7 cell viability, adhesion, and migration while elevating intracellular ROS, autophagy, and apoptosis in an amount-dependent way and that BLA may be a natural anti-cancer agent to prevent BC metastasis.
Xinyuan Niu, Periyannan Velu, A. Vijayalakshmi· Journal of Pharmaceutical In...· 0 citations
Findings provide the first evidence that PD16 exerts pro-apoptotic effects in CRC cells through the AKT/GSK3β pathway inhibition, thereby confirming it as a valuable novel therapeutic candidate for CRC.
M. Yao, Wei Zhang, Dong Xu et al.· European Journal of Pharmaco...· 0 citations
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