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Midkine-activated TRPA1+ cancer-associated fibroblasts promote immunotherapy resistance in gastric cancer through a WNT5A-mediated treg circuit

Hua-Long Zheng Xiao-Qian Ye Lin-Yong Zheng Xiao-Bo Huang Hai-Dan Yan Zhi-Long Lin Q. Zhong R. Tu Zhi-Quan Zhang You-Xin Gao Qiang Huang Yi-Fan Li Yi Li Xin-Peng Yang Chen-Yang Jiang Xiao-Jing Guo Mao-Sen Wang Chao-Hui Zheng Ping Li Jia-Bin Wang Jian-Xian Lin Chang-Ming Huang Qi-Yue Chen Jian-Wei Xie
Aug 2026 · Oncogene · Vol 45, pp. 4051 - 4064 · 0 citations · 40 references
Medicine

TL;DR

This study unveils an MDK-TRPA1 + CAF-mediated mechanism of ICB resistance in GC and highlights the WNT5A-SPP1+ macrophage pathway as a promising target to overcome immunotherapy resistance.

DOI PubMed Semantic Scholar
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