Aug 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 63 references
Medicine
TL;DR
This review critically examines purpurin-18 and related chlorin-based nanocarriers as next-generation photosensitizer systems for PDT to advance purpurin-18-based nano-PDT toward clinical applicability.
This study addresses triple-negative breast cancer treatment by developing a photosensitizer, DBC, with a multiple-twist molecular architecture, offering broader readers an impactful paradigm for engineering multi-functional biomaterials to combat aggressive cancers.
Photodynamic therapy (PDT) is an established clinically approved treatment; however, the development of next-generation photosensitizers remains constrained by the reliance on scarce precious-metal scaffolds and poor pharmacological properties. Earth-abundant first−row transition metals offer an attractive alternativ...
Zisis Papadopoulos, Aimée Marie Irgel, Alexandra König-Schäfer et al.· Journal of Medicinal Chemist...· 0 citations
Breast cancer is one of the most prevalent malignant tumors affecting women worldwide and poses a serious threat to women's health and survival. Accordingly, the development of effective technologies for breast cancer treatment has received considerable attention in biomedicine and materials chemistry. Here, push-pull...
Qi-Long Zhang, Xu Zhou, Xue Wang et al.· Journal of Colloid and Inter...· 0 citations
A novel lipid droplet-targeted aggregation-induced emission photosensitizer CTC was designed and synthesized, providing a novel candidate and new insight for safe and efficient breast cancer PDT.
Yukun Zhang, Lidong Deng, Qi-Yan Li et al.· Bioorganic chemistry (Print)· 0 citations
Overall, PDT combination design should be guided by whether adjunctive agents support or undermine photosensitizer accumulation, oxygen availability, ROS-mediated cytotoxicity, and immune activation, when selected according to mechanistic compatibility.
Ilaf Naser, D. Bartusik-Aebisher, Barbara Smolak et al.· Biomedicines· 1 citation
Photodynamic therapy (PDT) is a minimally invasive cancer treatment that works through the combined use of photosensitizers (PS), light, and molecular oxygen to generate reactive oxygen species. Several porphyrin-based photosensitizers have been clinically developed for PDT, with Photofrin being one of the most commo...
Gayathri M. P., Jotiba P. Powar, Balaji Babu· Molecular Pharmaceutics· 0 citations
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