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Intracellular pathogen targeting by IL32 elicits cell-autonomous immunity

Jeffrey R. Reitano Stephen C. Walsh Mary S. Dickinson Emma A. Johnston M. E. Cortina Haley E. Adcox Neal M. Alto I. Derré K. Hybiske R. Suchland So Young Kim J. Coers

Jul 2026 · bioRxiv · 0 citations

Medicine Biology

TL;DR

A potent immune surveillance and effector circuit executed by an intracellularly acting cytokine, IL32, that targets and restricts phylogenetically distinct vacuolar pathogens, including the bacterium Chlamydia and the microsporidian Encephalitozoon is discovered.

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