Author

Zun-Yuan Wang

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Sep 2026

Photochemical Synthesis of 1-Propyl-3-phenylquinoxalin-2(1 H )-one: An Undergraduate Laboratory Experiment

3-Arylquinoxaline-2(1H)-ones are significant scaffolds in medicinal chemistry due to their diverse biological and pharmacological activities, such as neuroprotective and anti-cancer activities. While photo-induced synthesis has emerged as a sustainable approach to these compounds, existing protocols often require exp...

You-Lu Pan, Jun Li, Zun-Yuan Wang et al. · Journal of Chemical Educatio... · 0 citations

Open access Jul 2026

Discovery of novel METTL3 inhibitors: design, synthesis, and in silico and in vitro evaluations

Methyltransferase-like protein 3 (METTL3) is a promising therapeutic target for Acute Myeloid Leukemia (AML). To discover novel METTL3 inhibitors, we designed a series of compounds by hybridizing the natural product Genistein and the non-nucleoside METTL3 inhibitor STM2457. Among the 31 de novo-generated compounds subj...

Yun Zhang, Meng-Yan Chen, Yanwen He et al. · RSC Advances · 0 citations