Zulema Rodriguez-Hernandez

Loss of the Y chromosome is transcriptionally silent in clear cell renal cell carcinoma and across cancer entities

Background Loss of the Y chromosome (LOY) is the most frequent somatic alteration in male cancers and has recently been linked to immune evasion, metabolic reprogramming and prognosis. Because the Y chromosome encodes transcriptional and epigenetic regulators, such as UTY and KDM5D, LOY is assumed to act through dysreg...