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Author

Zou Lee

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Sep 2026

Abstract B018: PPM1D- versus TP53-altered H3K27M-altered diffuse midline gliomas define distinct tumor states with isogenic modeling of Ppm1d-driven replication stress

H3K27M-altered diffuse midline glioma (DMG) is an aggressive pediatric brain tumor for which radiation is standard of care but only transiently delays progression. The oncogenic phosphatase PPM1D and the tumor suppressor TP53 both regulate DNA-damage-response (DDR) circuitry and are frequently mutated in H3K27M-alter...

Kate J. Lee, Abigail J. Groth, Ying-Ying Meng et al. · 0 citations

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