Jul 2026
Signal logic gate mediated by a controllable CRISPR/Cas12a system for simultaneous detection of DNA mutation and methylation.
A controllable CRISPR/Cas12a-based signal logic gate that enables simultaneous detection of KRAS G12C mutation and Septin9 promoter methylation in a single reaction and offers a simple and reliable platform for simultaneous genetic and epigenetic analysis in point-of-care cancer screening.
Zonghua Wen, Cong Wei, Meng Shen et al.
· Analytical Methods · 0 citations