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Author

Zong-Wei Li

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2 papers indexed here

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Review Sep 2026

IRF4 in multiple myeloma: From molecular mechanisms to therapeutic targeting.

Interferon regulatory factor 4 (IRF4) is a lineage-restricted transcription factor essential for plasma cell differentiation and represents an important dependency in multiple myeloma (MM). Unlike other IRF family members, IRF4 is primarily induced by antigen receptor signaling rather than interferon stimulation, linki...

Lu-Jin Wang, Xiao-Yu Wang, Peng Yang et al. · 0 citations
Open access Sep 2026

PTTG1-driven self-amplifying loop with SP1 and ENO1 promotes IRF4-mediated myeloma progression and bone destruction

A novel mechanistic insight is introduced into the pathogenesis of myeloma and bone deterioration and disruption of the ENO1–PTTG1 interaction is identified as a potential dual-targeting therapeutic strategy, demonstrating significant efficacy in curbing myeloma progression and osteolytic lesions.

Rui Liu, Ya-Zhu Huang, Z. Fang et al. · 0 citations

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