Zong-Wan Mao

Regulation of the Staphylococcus aureus stress response pathway by copper ions.

It is demonstrated that copper-associated oxidative perturbation modulates the DNA-binding activity of CtsR through a conserved cysteine residue, consistent with a copper-associated Cys37-dependent redox mechanism potentially coupling metal homeostasis, oxidative stress, and proteostasis regulation in S. aureus.