Zong-De Jiang

A Transformation-Guided Mass Spectrometry Workflow for Expanding In Vivo Metabolite Coverage and Revealing Noncanonical Metabolism of Epigallocatechin Gallate

In vivo metabolism of dietary bioactive compounds generates extensive chemical diversity, but much of this metabolite space remains inaccessible to current metabolomics workflows because of limited acquisition depth, database dependence, and insufficient structural validation. Here, we present a closed-loop analytica...