Author

Zong-Chao Chen

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Open access Aug 2026

Genome-integrated engineering of Escherichia coli Nissle 1917 enables sustained gut-local biosynthesis of 5-hydroxytryptophan

A genome-integrated engineered probiotic system enabling gut-local biosynthesis of 5-HTP was developed and results showed that the hTPH2 hydroxylation module, together with the BH4 biosynthesis and regeneration system, supported 5-HTP biosynthesis in EcN.

Jing Wu, Yifan Yang, Taiyu Li et al. · Synthetic and Systems Biotec... · 0 citations