Altered expression of ET-1 and HMGB1 together with higher MMP-9 activity in serum-derived exosomes of chronic lymphocytic leukemia.
Findings showed that serum-derived exosomes from CLL patients have higher expression of ET-1 and HMGB1 and higher MMP-9 enzymatic activity, which suggest that exosomal ET-1, HMGB1, and MMP-9 may serve as potential non-invasive biomarkers for disease monitoring and warrant further investigation regarding their biologica...