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MedGPT-oss: Training a General-Purpose Vision-Language Model for Biomedicine

This work introduces MEDGPT-OSS, an open-weight, 20B-parameter generalist vision-language model designed to facilitate open research in clinical AI, which successfully outperforms larger open medical models on out-of-distribution multimodal reasoning and complex text-only clinical tasks.

Kai Zhang, Zheng-Qing Yuan, Cheng Peng et al. · 0 citations
Open access Sep 2026

Less Can Be Better: Decomposing Clinical Data Modalities in Large Language Model-based Healthcare Applications

The benefits of multimodal data integration are task-dependent and healthcare LLMs should examine clinical data modalities according to specific tasks for efficient integration, and provide practical guidance for designing efficient clinical decision support systems.

Cheng Peng, Mengxian Lyu, Ziyi Chen et al. · 0 citations
Preprint Aug 2026

An Agentic Generative Large Language Model for Treatment Planning of Colorectal Cancer

GatorOnco, an agentic LLM for colorectal cancer treatment planning, is presented and it is demonstrated that integrating agentic reasoning with large-scale domain adaptation can help bridge the gap for generative AI in high-stakes cancer treatment planning.

Mengxian Lyu, Cheng Peng, Tim Jang et al. · 0 citations

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