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Zinab O. Doha

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Open access Aug 2026

Tumor-Intrinsic DNA Damage Signaling Is Associated with MHC-I Expression and CD8 Cytotoxic T-Cell Engagement in Triple-Negative Breast Cancer

An exploratory, integrative analysis using single-cell RNA sequencing of TNBC patients operationally stratified into Good and Bad Prognosis groups suggests a framework in which tumor-intrinsic DNA damage signaling is associated with MHC-I antigen presentation upregulation and CD8 cytotoxic T-cell engagement, supporting further investigation of this axis.

Zinab O. Doha, E. AbuAzzah, Hakeemah H Al-Nakhle · 0 citations

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