Author

Zil K. Modi

2 papers indexed here

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Open access Sep 2026

Pil-Chp orchestrates a multi-level regulatory system to control type IV pilus dynamics in Pseudomonas aeruginosa

Analysis of individual pilus dynamics across mutants covering the entire T4P system of Pseudomonas aeruginosa identified active pili in several mutants previously classified as non-piliated, and demonstrated that these regulatory mechanisms of T4P length and count differentially impact T4P-dependent functions.

Farhana Haque, Zil K. Modi, Lincon Mazumder et al. · bioRxiv · 1 citation

Open access Jun 2026

Machine Learning-Guided Discovery of Bacterial-Selective Membrane-Active Compounds Reveals Mechanistic Bias in Antibiotic Training Datasets

A machine learning pipeline is presented that addresses chemical novelty upfront by employing an XGBoost-based MoA classifier to explicitly prioritize compounds predicted to have mechanisms distinct from known antibiotic classes, combined with graph neural networks for antibacterial activity and toxicity prediction.

Connor Chain, Soodabeh Ghaffari, Syrine Belakaria et al. · bioRxiv · 0 citations