Author

Zi-Hao Zhang

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Case report Open access Sep 2026

Treatment of an Advanced NSCLC Patient with a Rare OSBPL9-ALK Fusion: A Case Report

ALK rearrangements define an important molecular subtype of lung adenocarcinoma, and the rearranged ALK serves as a well-established oncogenic driver in this malignancy. The most common type of mutation is the EML4-ALK fusion. Meanwhile, rare fusions are also frequently discovered with regard to ALK. However, clinical...

Liang Chen, Hu Chen, Le-Yuan Feng et al. · Healthcare · 0 citations

Aug 2026

TL1A(TNFSF15)-ENO1 axis promotes osteoarthritis by disrupting redox homeostasis via the PI3K/AKT pathway.

OBJECTIVE Osteoarthritis (OA) is characterized by cartilage degeneration, oxidative stress, and chondrocyte senescence. This study investigated whether TL1A promotes OA through ENO1-associated redox, senescence and PI3K-AKT signaling mechanisms. METHOD Human paired OA cartilage, primary chondrocytes, and mouse age-as...

Xiang Gao, Jun-Tan Li, Chang-Yu Yin et al. · Osteoarthritis and Cartilage · 0 citations