Open access
Aug 2026
WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis
ABSTRACT Osteoporosis, characterized by imbalanced bone homeostasis, is driven by excessive osteoclast‐mediated bone resorption, yet the epitranscriptomic regulation via m6A modification remains unclear. Here, we identify WTAP, a component of the m6A methyltransferase complex, as a critical negative regulator of osteoc...
Chen Shen, Xin Liu, Gao-Ran Ge et al.
· Advancement of science · 0 citations