Author

Zi-Yi Li

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Open access Oct 2026

Neutrophils orchestrate pre-metastatic immunosuppressive bone marrow remodeling during prostate cancer metastasis

The dynamic reprogramming of the bone marrow (BM) microenvironment during metastatic progression is poorly defined. Through single-cell profiling of BM samples spanning benign conditions, high-risk bone metastatic potential localized prostate cancer (HMP) and established bone metastatic prostate cancer (PCa), we uncove...

Ying-Kui Tang, Xuan Zhou, Duo-Cai Li et al. · bioRxiv · 0 citations

Jul 2026

Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma.

This work integrated single-cell profiling and spatial transcriptomics of glioma-associated microglia in the GL261 model to identify distinct microglial states that aligned with tumor architecture and highlighted microglial state transitions as a stage-specific layer of immune regulation in glioma that shapes T cell fa...

Jia-Wen Qian, Chen Wang, Yi Zhang et al. · Immunity · 0 citations