Author

Zi-Xuan Chen

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Open access Sep 2026

Therapeutic Potential of the Deubiquitinase BRCC3 in Attenuating Ischemic Myocardial Injury and Ventricular Remodeling

It is demonstrated that BRCC3 protects against ischemic injury and pathological remodeling by deubiquitinating Smad3 at K333 to antagonize TGF-β1/Smad3 signaling, identifying BRCC3 as a potential therapeutic target for preventing post-AMI heart failure.

De-Shan Yao, Si-Chuan Wang, Ru-Jun Li et al. · Research · 0 citations

Review Open access Aug 2026

Microglial immunosurveillance after ischemic stroke: dynamic phenotypes, neurovascular interactions, and therapeutic opportunities

Therapeutic strategies should seek to redirect specific microglial programs rather than broadly suppress neuroinflammation, and potential approaches include modulating inflammasome and complement signaling, oxidative stress, phagocytosis, lipid metabolism, and repair-associated trophic functions.

Yingshi Bao, Zi-Xuan Chen, Xian Jia · Frontiers in Immunology · 0 citations