Author

Zi-Rui Wang

3 papers indexed here

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Open access Aug 2026

Profiling the tumor microenvironment of a hepatocellular carcinoma patient with primary resistance to immunotherapy plus anti-angiogenic therapy but exceptional response to chemotherapy plus bevacizumab

Hepatocellular carcinoma (HCC) with extrahepatic metastasis (EHM) carries a poor prognosis, and treatment options after failure of anti-angiogenic targeted agents combined with immune checkpoint inhibitor (ICI) remain limited. An adult patient with advanced HCC exhibited primary resistance to three sequent...

Qin Xu, Rui Zhu, Zi-Rui Wang et al. · Journal of Cancer Research a... · 0 citations

Open access Sep 2026

Gefitinib-based therapy in refractory hepatocellular carcinoma with EGFR overexpression: a spatial profiling-guided case report

A case of a patient with advanced HCC who developed cutaneous, pulmonary, and lymphatic metastases following failure of multiple lines of tyrosine kinase inhibitors including donafenib and regorafenib is presented, highlighting the potential benefit of an EGFR-targeted triplet strategy in refractory HCC with EGFR prote...

Qin Xu, Xiao-Fen Li, Rui Zhu et al. · Frontiers in Immunology · 0 citations

Aug 2026

Establishing a genetic mutation panel for predicting malignant transformation of oral leukoplakia: A prospective cohort study.

A 3-gene mutational panel as risk stratification model could effectively predict OLK malignant transformation, outperforming pathological grading-based assessment and may provide a foundation for developing personalized management strategies.

Yuhan Zhu, Zi-Rui Wang, Chen-Xi Li et al. · Oral Oncology · 0 citations