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Zi-Rong Chen

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Aug 2026

Cryo-EM structure of the WDR11-FAM91A1-C17orf75 complex involved in retrograde trafficking.

Functional analyses demonstrate that C17orf75 is indispensable for the proper intracellular localization of the acidic-cluster-containing cargo proteins CI-MPR, KIAA0319L, and VAMP4 and establish C17orf75 as an integral component of the WFC complex in endosome-to-TGN trafficking.

Yifan Zhang, Zhi-Min Liu, Zi-Rong Chen et al. · 1 citation

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