Author

Zi-Mei Wang

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Open access Oct 2026

METTL14‐Mediated m6A Methylation Preserves Cardiomyocyte Homeostasis and Attenuates Progeria‐Associated Cardiac Remodeling

Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disorder most commonly caused by a de novo synonymous mutation (c.1824C>T) in the LMNA gene. This mutation activates aberrant splicing of prelamin A, leading to the production and accumulation of progerin, which drives accelerated aging, with patient...

Shi-Xiao Wang, Jie Zhang, Ying Ao et al. · Aging Cell · 0 citations

Open access Aug 2026

CK2α restriction of STING accumulation underlies systemic aging

This work identifies lamin A/C (LMNA) as a critical NE scaffold that orchestrates STING regulation by recruiting both STING and Casein Kinase 2 (CK2α), and establishes the LMNA-CK2-STING axis as a key biochemical mechanism that suppresses innate immune activation at the NE.

Jie Zhang, Mei-Ling Jin, Dan Rao et al. · Nature Communications · 0 citations