A novel renoprotective mechanism of Phellodendri Chinensis Cortex in uric acid nephropathy: targeting PFKFB3-glycolysis-macrophage axis.
ETHNOPHARMACOLOGICAL RELEVANCE Phellodendri Chinensis Cortex (PCC), a classic herb for "clearing heat and drying dampness," is traditionally used to treat gout and uric acid nephropathy (UAN) for its urate-lowering and nephroprotective properties. Yet, the mechanism of its direct renoprotective effect remains unclear....