Author

Zihao Wen

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Open access Oct 2026

PLA2G4A-driven arachidonic acid metabolic reprogramming promotes NSCLC progression via the HSF1 signaling axis

Aberrant arachidonic acid (AA) metabolism is a hallmark of cancer, and cytosolic phospholipase A2 (PLA2G4A) is the rate-limiting enzyme that initiates this cascade. However, the cell-intrinsic role of PLA2G4A and its downstream signaling mechanisms in non-small cell lung cancer (NSCLC) remain poorly understood. Her...

Wei-Fang Wang, Ze Wang, Kun-Fang Li et al. · Cell Death Discovery · 0 citations

#protein folding Open access Aug 2026

A binding-to-release strategy for targeted anticancer drug delivery

A framework that overcomes the internalization barrier, broadening the target scope for therapeutic and diagnostic conjugates is established and extended BTR to programmed cell death ligand 1 (PD-L1) and an mRNA-display-derived FAP peptide, suggesting potential broad applicability.

Zi-Hao Wen, Meng-Xin Xu, Zi-Jun Yan et al. · Nature · 1 citation