Zi-Chuan Song

Enhanced rAAV Production in HEK293 Cells by Promoting Helper Plasmid Nuclear Import Under HDAC6 Inhibition.

Recombinant adeno-associated virus (rAAV) vectors have emerged as leading platforms for gene therapy owing to their safety, long-term transgene expression, and broad tissue tropism. However, rAAV production in HEK293 cells via triple-plasmid transfection remains limited by low yield, partly due to inefficient nuclear i...