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Zi-Chao Guo

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Open access Oct 2026

Rational Design Principles for Cell Membrane Coating of Nanoparticles

Cell membrane coating offers a biomimetic strategy for drug delivery by combining the biological functions of natural membranes with the tunable properties of synthetic nanoparticles (NPs). The coating process influences membrane coverage and the biological performance of the resulting particles, making the selection o...

Moataz B. Zewail, Yun Liu, Yi-Long Fan et al. · 0 citations
Open access Sep 2026

Mechano-Chemical Coordination of Nanoparticle-Based Artificial Antigen-Presenting Cells Synergistically Tunes T Cell Activation and Expansion Phenotypes.

Particle-based artificial antigen-presenting cells (aAPCs) are widely used for ex vivo T cell activation, but rigid, high-avidity stimulation can promote differentiation and exhaustion, reducing therapeutic efficacy. Because T cells sense mechanical forces through the T cell receptor, we engineered nanocapsule aAPCs wi...

Zi-Chao Guo, Fei Hou, Ya-Li Zhang et al. · 0 citations

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