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Zhuo-Ying Chen

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Open access Sep 2026

Sleep Disturbance Correlates with Cognitive Impairment Partly via Plasma p-Tau217: ADNI Cross-Sectional Evidence and P301L Mouse Mechanistic Observations

How sleep disturbances link to cognitive decline in Alzheimer’s disease (AD) via tau pathology is unclear. We explored whether sleep dysfunction worsens cognitive deficits by elevating plasma phosphorylated tau217 (p-Tau217). We combined Alzheimer’s Disease Neuroimaging Initiative (ADNI) human cohort mediation analysis...

Qiong Zheng, Run-Shuang Liu, Bei-Rui Chen et al. · 0 citations

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