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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Zhuo-Jun Luo

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#protein folding Sep 2026

Tideglusib as a First-in-Class Chemical Probe for NatA: Identification, Mechanism, and Cellular Validation of an Allosteric, CoA-Dependent Inhibitor.

Tideglusib is established as a mechanistic chemical probe for NatA, NatA is revealed as a previously unrecognized molecular target for a promiscuous clinical-stage investigational compound, and a conceptual framework for exploiting catalysis-dependent adduct formation as a new strategy for acetyltransferase inhibitor d...

Youchao Deng, Zhuo-Jun Luo, Sarah M. Gardner et al. · 0 citations

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