Whole-transcriptome profiling of the fat body identifies aae-miR-283-ApoLp-Ⅱ/Ⅰ regulation associated with lipid transport and ovarian development in Aedes aegypti.
Functional studies revealed that both aae-miR-283 overexpression and ApoLp-Ⅱ/Ⅰ knockdown disrupted lipid homeostasis, increasing triacylglycerol accumulation in the fat body while depleting ovarian lipid stores, supporting a role for aae-miR-283-ApoLp-Ⅱ/Ⅱ regulation in lipid transport from the fat body to the ovaries.