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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Zhuangzhuang Zhang

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Review Open access Aug 2026

AR-V7-Driven Mitochondrial Metabolic Reprogramming in Enzalutamide-Resistant Prostate Cancer: Mechanisms and Therapeutic Implications

Enzalutamide resistance in castration-resistant prostate cancer (CRPC) is frequently driven by androgen receptor splice variant 7 (AR-V7), a prognostic biomarker that lacks the ligand-binding domain and evades enzalutamide inhibition; however, the downstream metabolic networks sustaining resistant-cell survival remain...

Rong-Xin Chang, Zhuangzhuang Zhang · 0 citations

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