Author

Zhongsong Zhang

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Review Open access Sep 2026

Precision Multimodal Nanodynamic Therapy for Lung Cancer: From Tumor Microenvironment-Responsive Platforms to Cell-Death Reprogramming and Immune Remodeling

Abstract Lung cancer remains one of the most prevalent and lethal malignancies worldwide and is characterized by a complex tumor microenvironment (TME), including severe hypoxia, acidosis, elevated glutathione levels, and pronounced immunosuppression. These pathological conditions compromise the efficacy of conventiona...

Keyi Gou, Zhong-Song Zhang, Si-Xian Yi et al. · International Journal of Nan... · 0 citations

Review Open access Sep 2026

Nanomedicine-Empowered CAR-T Therapy for Multiple Myeloma: Toward Programmable, Durable, and Precision Immunotherapy

This review systematically examines the major biological mechanisms underlying relapse after CAR-T therapy in MM, with particular emphasis on both the therapeutic potential of nanotechnology and the translational challenges associated with CAR-T manufacturing optimization, in vivo immune programming, bone marrow microe...

Can Huang, Xu-Yan Zhang, Yuanyin Teng et al. · International Journal of Nan... · 0 citations

Review Open access Aug 2026

Engineering Multimodal Nanomaterials for Prostate Cancer Theranostics: Design Principles, Recent Advances, and Translational Challenges

Overall, nanomedicine may support more precise, minimally invasive, and integrated PCa management, but successful translation will require standardized characterization, scalable manufacturing, rigorous safety evaluation, clinically relevant validation, and rational integration with established diagnostic and therapeut...

Jia Wang, Zhong-Song Zhang, Haihao Li et al. · International Journal of Nan... · 0 citations