Multigene-Edited Pig-to-Rhesus-Macaque Liver Xenotransplantation: Multifaceted Profiling-of-Post-transplant Phenotypes.
Although xenoantigen knockout effectively averts HAR, irreversible coagulation-cascade activation, thrombosis and consumptive coagulopathy still represent the principal barriers to long-term xenograft survival even in the setting of donor-expressed human anticoagulant transgenes hTBM, hCD39, and hEPCR.