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Zhong-Yuan Chen

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Open access Sep 2026

Enhanced production of phomapyrrolidone a through culture-condition optimization and morphological regulation in Didymella sp. FATR0054

Phomapyrrolidone A (Ppd A) is a hirsutellone-type macrocyclic alkaloid derived from marine fungi, exhibiting significant activity against triple-negative breast cancer (TNBC). However, its low fermentation yield has limited further drug development. This study established a systematic optimization strategy integrating...

Wei-Yan Zhou, Zhong-Yuan Chen, Jia-Cheng Guo et al. · 0 citations

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