Review
Open access
Sep 2026
Tryptophan metabolism: a critical bridge linking gut microbiota to depression
Depression is a major global public health challenge with limitations in current therapies. Emerging evidence highlights that gut microbiota (GM) critically regulates the gut-brain axis via tryptophan (Trp) metabolism. Trp is metabolized through host-directed serotonin (5-HT) and kynurenine (KYN) pathways, as well as m...
Hao-Yuan Tan, Yu-Xin Pang, Qiao-Yu Ji et al.
· Frontiers in Microbiology · 0 citations