Author

Zhong-Gao Gao

5 papers indexed here

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Aug 2026

Polysaccharide-functionalized metal-polyphenol network-coated porous microspheres for improving the treatment of probiotics in ulcerative colitis.

Probiotic therapy offers a new approach to the treatment of ulcerative colitis (UC), but oral drug delivery still faces challenges such as low gastrointestinal survival rates, insufficient intestinal retention, and poor inflammatory targeting. In this study, a layer-by-layer encapsulation probiotic delivery system (HGM...

Congcong Xiao, Bo-Han Chen, Li-Ming Gong et al. · International journal of pha... · 0 citations

Open access Sep 2026

Thymine-functionalized bPEI nanocomplexes for synergistic STING activation and PD-L1 silencing to potentiate cancer immunotherapy.

Cancer continues to pose a major global health burden. Although immunotherapy has reshaped treatment strategies, its therapeutic effect is frequently limited by a suppressive tumor microenvironment and systemic toxicity. The stimulator of interferon genes (STING) pathway has emerged as a key target for coordinating inn...

Li-Qing Chen, Mong-Hsiu Song, Ming-Ji Jin et al. · Journal of Controlled Releas... · 0 citations

Sep 2026

Mechanically adaptive dual-crosslinked hydrogel integrated with metal-phenolic cell backpacks for active keloid therapy.

Keloids are invasive, highly recurrent fibroproliferative disorders. Clinical samples reveal a pathological pattern characterized by dysregulated extracellular matrix (ECM) remodeling, reduced NK-cell infiltration, and elevated TGF-β1. Current monotherapies have limited efficacy, and local delivery systems fail to achi...

Shuang-Qing Wang, Shi-Qi Huang, Jing-Yu Jin et al. · Journal of Controlled Releas... · 0 citations

Aug 2026

Self-sustaining ROS-responsive hydrogel enabled delivery of PROTAC/Ce6 nanoparticles via PDT-Epigenetic protein degradation to amplify pyroptosis for enhanced cancer immunotherapy.

Cancer immunotherapy exhibits limited efficacy in immunologically "cold" tumors due to insufficient T-cell infiltration and immunosuppressive tumor microenvironment. The efficacy of photodynamic therapy (PDT) is restricted by inadequate tumor-specific aggregation of photosensitizers and therapeutic resistance regulated...

Li-Ming Gong, Jing Feng, Li-Qing Chen et al. · Biomaterials · 0 citations

Review Open access Sep 2026

Research Advances on Organelle-Targeted Drug Delivery Systems for the Treatment of Brain Tumors and Central Nervous System Inflammation

Central nervous system (CNS) inflammation and brain tumor treatment are constrained by the heterogeneity of the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB), as well as by the sequential barriers to drug delivery across lesions, target cells and subcellular organelles. Simply increasing brain exposure...

Man-Ru Zhang, Bo-Han Chen, Tie-Zheng Li et al. · Pharmaceutics · 0 citations