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Zhong-Chen Li

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Review Open access Aug 2026

Short-chain fatty acids as key mediators of the microbiota–gut–brain axis in chronic cerebral hypoperfusion: mechanisms and therapeutics

Chronic cerebral hypoperfusion (CCH) is an important contributor to vascular cognitive impairment and neurodegenerative disorders, characterized by neuronal injury, blood–brain barrier (BBB) disruption, neuroinflammation, mitochondrial dysfunction, and synaptic impairment. Increasing evidence suggests that the microbio...

Jun-Chen Si, Pei-Jian Wang, Zhong-Chen Li et al. · 0 citations

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