Tetrastigma hemsleyanum polysaccharides ameliorate inflammatory bowel disease via sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 -mediated gut vascular barrier repair.
It is demonstrated that THP alleviates IBD by repairing the GVB through the S1P/S1PR2 axis, providing a mechanistic basis for GVB-targeted therapeutic strategies.