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Open access Sep 2026

Toxoplasma gondii infection disrupts secondary bile acid transformation in feline gut microbiota

ABSTRACT Bile acid (BA) transformation relies on gut microbiota and is vulnerable to Toxoplasma gondii infection, yet feline microbial BA-transforming capacity upon toxoplasmosis remains unclear. Here, we constructed a catalog of 2,474 nonredundant feline gut microbial genomes and integrated serum metabolomic data to v...

Lu-Yao Tang, He Zhang, Ji-Xin Zhao et al. · 0 citations
Open access Aug 2026

A Live Attenuated AP2X-1-Deficient Toxoplasma Strain Confers Protective Immunity Against Acute and Chronic Toxoplasmosis in a Murine Model

Simple Summary Toxoplasmosis, caused by the zoonotic parasite Toxoplasma gondii, is a major concern for immunocompromised individuals and the livestock industry. Research has shown that AP2X-1 is important for growth, conversion between tachyzoites and bradyzoites, and sexual stage development of T. gondii. In the pres...

Wen-Bo Hao, Li-Xiu Sun, Ru-Shi Tu et al. · 0 citations

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