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A link between systemic inflammatory burden and hippocampal vulnerability is supported, while relationships with AD pathology and clinical progression warrant further investigation.
The latest developments in connectome-based modeling of the suicidal brain can not only inform neurobiological mechanisms but also help to advance clinical translation, and a novel paradigm using normative models to develop a connectome-based suicide risk calculator is proposed.
This study investigated the neural and molecular bases of individual differences in adolescent MDD patients by integrating a novel edge-centric brain connectome with transcriptomic and neurotransmitter profiles, and identified two robust adolescent MDD subtypes.
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