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Zhi-Yuan Zhang

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Review Open access Aug 2026

Integrin α4β7: Pathogenic Roles in Metabolic and Inflammatory Diseases and Translational Therapeutics

Abstract Integrin α4β7 is a key adhesion receptor that mediates lymphocyte homing to the intestinal mucosa through interactions with MAdCAM-1, VCAM-1, and fibronectin, thereby playing a central role in gut immune surveillance and mucosal immunity. Emerging evidence has expanded its functional scope beyond intestinal ho...

Yue Chen, Yong Chen, Zhi-Yuan Zhang et al. · 0 citations

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