Author

Zhi-Yuan Song

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Open access Sep 2026

GraPPI: A Self-Supervised Graph Encoder for Transferable Protein–Protein Interaction Modeling

Protein–Protein Interactions (PPIs) are fundamental to cellular processes and represent major targets for therapeutic development. Recent advances in machine learning for protein modeling, particularly protein language models, have enabled powerful representations of protein sequences and monomeric structures. However,...

Zhi-Yuan Song, Zi-Yu Shi, Gary Sun et al. · bioRxiv · 0 citations

Open access Aug 2026

Multi-dimensional attention framework for personalised Alzheimer's disease progression prediction across sporadic and genetic risk cohorts

Alzheimer's disease progresses heterogeneously across diverse cohorts, yet current predictive models fail to capture this complexity while remaining clinically interpretable. Here we present a multi-dimensional attention framework that simultaneously captures both temporal dynamics and biomarker importance to predict d...

Zhi-Yuan Song, Si-Yang Song, Isabel C. H. Clare et al. · Research Square · 0 citations